The ingredient, explained

Acetyl Tetrapeptide-5

A preliminary conference report examined acetyl tetrapeptide-5 around the eyes.

HumectantPeptide

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Ingredient guide

What it is and what it does

Acetyl Tetrapeptide-5 is product obtained by the acetylation of Tetrapeptide-5

About this ingredient: EU CosIng ingredient registry (via Open Beauty Facts taxonomy) ↗

Humectant: Helps attract and retain moisture.
Peptide: An ingredient made from linked amino-acid units. The peptide name identifies a particular material, not a shared clinical effect for all peptides.

Function definitions: European Commission: Cosmetic peptide nomenclature ↗

Registry functions describe possible formulation roles, not results for a finished product. A dictionary entry is not an approval or a safety assessment.

A closer look

What the research shows

Preliminary conference report

It reported lower erythema measurements and visible puffiness improvement.

What this does not tell us

Sample size and blinding are unknown. The short report did not establish melanin lightening and needs independent replication.

Sources for this summary. Published source ↗

Research review checked Oct 1, 2026

Read exact local candidate abstracts first; select identity-relevant papers; targeted primary PubMed/publisher searches. This is not an exhaustive systematic review.