The ingredient, explained

Betulin

Research examined BETULIN under the stated study conditions.

Skin conditioning

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Ingredient guide

What it is and what it does

Lup-20-29--ene-3‚28-diol, -3β--

About this ingredient: EU CosIng ingredient registry (via Open Beauty Facts taxonomy) ↗

Skin conditioning: A broad cosmetic role for maintaining skin condition. It does not identify a particular clinical benefit.

Function definitions: European Commission ingredient function definitions (SCCNFP/0299/00, pages 16 to 20) ↗

Registry functions describe possible formulation roles, not results for a finished product. A dictionary entry is not an approval or a safety assessment.

A closer look

What the research shows

Laboratory and human research

Betulin-loaded nanocarriers reduced selected UV/heat damage markers in cell/skin models and the small human pilot.

What this does not tell us

12 participants, 2 weeks. Specific arginine-caprylate nanocarrier and 3% carrier cream, not 3% pure betulin. Findings do not establish long-term anti-aging effects of conventional betulin formulas.

Sources for this summary. PubMed 42175889 ↗

Research review checked Oct 1, 2026

Review supplied candidate titles and available abstracts selectively for exact identity; targeted primary PubMed/publisher searches. This is not an exhaustive systematic review.

Review source 1 ↗

Ingredient research is not proof that a product containing this ingredient works.

Read the 1 selected study

Laboratory and human research · n=12
Reduction of Ultraviolet- and Heat-Induced Aging Using Betulin-Loaded Arginine-Caprylate Self-Assembly: Randomized Double-Blind Clinical Trials. ↗
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026

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