The ingredient, explained

Dipotassium Glycyrrhizate

Dipotassium glycyrrhizate has human research within a multi-ingredient emollient.

HumectantAnti-inflammatoryTyrosinase inhibitor / brighteningSkin conditioning

Ingredient guide

What it is and what it does

.alpha.-d-Glucopyranosiduronic acid, -3.beta.,20.beta.--20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-d-glucopyranuronosyl-, dipotassium salt

About this ingredient: EU CosIng ingredient registry (via Open Beauty Facts taxonomy) ↗

Humectant: Helps attract and retain moisture.
Anti-inflammatory: Research category concerning reduced inflammation. A discovery tag does not establish that an ingredient treats inflammation at the amount used in a product.
Tyrosinase inhibitor / brightening: Research category for changes in pigmentation or uneven skin tone. The label does not establish that a finished product changes pigmentation.
Skin conditioning: A broad cosmetic role for maintaining skin condition. It does not identify a particular clinical benefit.

Function definitions: European Commission ingredient function definitions (SCCNFP/0299/00, pages 16 to 20) ↗ · National Cancer Institute: Anti-inflammatory definition ↗ · Original niacinamide study: Pigmentation and hyperpigmented spots ↗

Registry functions describe possible formulation roles, not results for a finished product. A dictionary entry is not an approval or a safety assessment.

A closer look

What the research shows

Human research on a combination

The complete emollient improved hydration and reduced water loss relative to an untreated leg.

What this does not tell us

No vehicle control and an unblinded combination design prevent attributing the effect to dipotassium glycyrrhizate alone.

Sources for this summary. PubMed 42108609 ↗

Research review checked Oct 1, 2026

Bounded review of supplied local candidates (2 candidate records), selective exact-name title/abstract screening, and targeted indexed primary-source searches. Not a systematic review or a claim of exhaustive coverage.