The ingredient, explained

Hexapeptide-11

Selected evidence concerns in vitro and human topical experiment.

PeptideSkin conditioning

Explore connections

Ingredient guide

What it is and what it does

Hexapeptide-11 is a synthetic peptide containing Alanine, Phenylalanine, Proline and Valine residues

About this ingredient: EU CosIng ingredient registry (via Open Beauty Facts taxonomy) ↗

Peptide: An ingredient made from linked amino-acid units. The peptide name identifies a particular material, not a shared clinical effect for all peptides.
Skin conditioning: A broad cosmetic role for maintaining skin condition. It does not identify a particular clinical benefit.

Function definitions: European Commission ingredient function definitions (SCCNFP/0299/00, pages 16 to 20) ↗

Registry functions describe possible formulation roles, not results for a finished product. A dictionary entry is not an approval or a safety assessment.

A closer look

What the research shows

Laboratory and human research

Peptide activated cell-protection pathways in fibroblasts; a small topical experiment reported improved skin elasticity.

What this does not tell us

Cell outcomes dominate evidence. Twenty-five volunteers and four-week toner experiment; randomization/blinding not established, with Lonza involved in the human assay.

Sources for this summary. PubMed 25974626 ↗

Research review checked Oct 1, 2026

Bounded review of 0 local candidate titles, selected relevant local abstracts, and targeted primary-source web searches. Not an exhaustive systematic review.

Ingredient research is not proof that a product containing this ingredient works.