The ingredient, explained

Methyl Estradiolpropanoate

A pilot trial studied topical methyl estradiolpropanoate in postmenopausal women.

EmollientSkin conditioning

Explore connections

Ingredient guide

What it is and what it does

Estra-1‚3,5-10--triene-16-propanoic acid, 3‚17-dihydroxy-, methyl ester, -16.\a-.,17.\b-.--

About this ingredient: EU CosIng ingredient registry (via Open Beauty Facts taxonomy) ↗

Emollient: Helps soften and smooth the skin surface.
Skin conditioning: A broad cosmetic role for maintaining skin condition. It does not identify a particular clinical benefit.

Function definitions: European Commission ingredient function definitions (SCCNFP/0299/00, pages 16 to 20) ↗

Registry functions describe possible formulation roles, not results for a finished product. A dictionary entry is not an approval or a safety assessment.

A closer look

What the research shows

Human topical research

Several investigator-rated appearance measures improved relative to vehicle.

What this does not tell us

Industry-funded single-site pilot; long-term safety and other populations were not established.

Sources for this summary. PubMed 30500138 ↗

Research review checked Oct 1, 2026

Read exact local candidate abstracts first; select identity-relevant papers; targeted primary PubMed/publisher searches. This is not an exhaustive systematic review.

Ingredient research is not proof that a product containing this ingredient works.