The ingredient, explained
Natamycin
A large randomized trial examined natamycin for fungal corneal ulcers.
Ingredient guide
What it is and what it does
6‚11‚28-Trioxatricyclo[22.3.1.05‚7]octacosa-8‚14‚16‚18‚20-pentaene-25-carboxylic acid, 22-[-3-amino-3‚6-dideoxy-.beta.-D-mannopyranosyl-oxy]-1‚3,26-trihydroxy-12-methyl-10-oxo-, -1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S--
About this ingredient: EU CosIng ingredient registry (via Open Beauty Facts taxonomy) ↗
- Antimicrobial
- A technical role associated with controlling microorganisms on skin.
- Preservative
- Helps inhibit microbial growth in the cosmetic product.
Function definitions: European Commission ingredient function definitions (SCCNFP/0299/00, pages 16 to 20) ↗
Registry functions describe possible formulation roles, not results for a finished product. A dictionary entry is not an approval or a safety assessment.
A closer look
What the research shows
Human eye treatment study
It outperformed voriconazole on disease-specific outcomes.
What this does not tell us
Eye-infection therapy does not establish cosmetic skin benefit.
Sources for this summary. PubMed 23710492 ↗
Research review checked Oct 1, 2026
Review supplied candidate titles and available abstracts selectively for exact identity; targeted primary PubMed/publisher searches. This is not an exhaustive systematic review.
Ingredient research is not proof that a product containing this ingredient works.
Read the 1 selected study
Human eye treatment study · n=323
The mycotic ulcer treatment trial: a randomized trial comparing natamycin vs voriconazole. ↗
JAMA ophthalmology · 2013
Follow the formula
Products containing this ingredient
From the wider catalogue. Linked by the ingredient list, without an efficacy ranking.
Names and identifiers
Registry identity
6‚11‚28-Trioxatricyclo[22.3.1.05‚7]octacosa-8‚14‚16‚18‚20-pentaene-25-carboxylic acid, 22-[-3-amino-3‚6-dideoxy-.beta.-D-mannopyranosyl-oxy]-1‚3,26-trihydroxy-12-methyl-10-oxo-, -1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S--
- INCI name on ingredient lists
- NATAMYCIN
- CAS registry number
- 7681-93-8
- EC number
- 231-683-5 I
Sources for this ingredient record
- EU CosIng ingredient registry (via Open Beauty Facts taxonomy) ↗ · ODbL 1.0 (Open Beauty Facts database) · Recorded Aug 8, 2026
