The ingredient, explained
Sh-polypeptide-45
sh-Polypeptide-45 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is synthesized to be identical to the human gene which codes for Granulocyte Macrophage Colony Stimulating Factor. It contains a maximum of 144 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids
Ingredient guide
What it is and what it does
About this ingredient: EU CosIng ingredient registry (via Open Beauty Facts taxonomy) ↗
- Skin conditioning
- A broad cosmetic role for maintaining skin condition. It does not identify a particular clinical benefit.
Function definitions: European Commission ingredient function definitions (SCCNFP/0299/00, pages 16 to 20) ↗
Registry functions describe possible formulation roles, not results for a finished product. A dictionary entry is not an approval or a safety assessment.
A closer look
What the research shows
We have not yet published a checked study for this exact ingredient. This is a gap in our coverage, not a finding that research does not exist or that the ingredient is ineffective.
Ingredient research is not proof that a product containing this ingredient works.
Follow the formula
Products containing this ingredient
From the wider catalogue. Linked by the ingredient list, without an efficacy ranking.
Names and identifiers
- INCI name on ingredient lists
- SH-POLYPEPTIDE-45
Sources for this ingredient record
- EU CosIng ingredient registry (via Open Beauty Facts taxonomy) ↗ · ODbL 1.0 (Open Beauty Facts database) · Recorded Aug 8, 2026