The ingredient, explained

Subtilisin

A small exposure study examined subtilisin in already sensitized patients.

KeratolyticSkin conditioning

Explore connections

Ingredient guide

What it is and what it does

Enzymes, subtilisin

About this ingredient: EU CosIng ingredient registry (via Open Beauty Facts taxonomy) ↗

Keratolytic: A technical role associated with removing cells from the outer skin layer.
Skin conditioning: A broad cosmetic role for maintaining skin condition. It does not identify a particular clinical benefit.

Function definitions: European Commission ingredient function definitions (SCCNFP/0299/00, pages 16 to 20) ↗

Registry functions describe possible formulation roles, not results for a finished product. A dictionary entry is not an approval or a safety assessment.

A closer look

What the research shows

Human exposure research

Responses differed by detergent granulation and washing/rinsing conditions.

What this does not tell us

Selected allergy patients and mixed exposure routes cannot establish cosmetic-user risk or benefit.

Sources for this summary. PubMed 589771 ↗

Research review checked Oct 1, 2026

Review supplied candidate titles and available abstracts selectively for exact identity; targeted primary PubMed/publisher searches. This is not an exhaustive systematic review.

Ingredient research is not proof that a product containing this ingredient works.