Human topical research
Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study.
Arzneimittel-Forschung · 2000
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Topical dexpanthenol in two lipophilic vehicles versus their vehicles for seven days. The abstract does not report concentration or sample size.
Checked against the published abstract on Sep 30, 2026. Read the source ↗
Abstract
In a randomized, double-blind, placebo-controlled study the effect of topical dexpanthenol (CAS 81-13-0) formulated in two different lipophilic vehicles on epidermal barrier function in vivo was carried out. Seven days' treatment with dexpanthenol improved stratum corneum hydration and reduced transepidermal water loss. Active treatment was statistically different from the vehicle control on both measures. Our results suggest that topical dexpanthenol formulated in either lipophilic vehicle stabilizes the skin barrier function.
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