Safety assessment of poloxamers 101, 105, 108, 122, 123, 124, 181, 182, 183, 184, 185, 188, 212, 215, 217, 231, 234, 235, 237, 238, 282, 284, 288, 331, 333, 334, 335, 338, 401, 402, 403, and 407, poloxamer 105 benzoate, and poloxamer 182 dibenzoate as used in cosmetics.

What was studied

Panel judged assessed poloxamers safe in described cosmetic uses; impurity controls are part of the assessment. Dated group read-across; cosmetic levels cannot be extended to high-dose intravenous exposure. Local anal-fissure paper uses polymer as delivery vehicle, not efficacy agent.

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