Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.

What was studied

Eight-week four-arm trial in women aged at least 40: oral placebo or 75 mg trans-resveratrol capsules plus matched cream vehicle or 1.5% trans-resveratrol cream, both twice daily. Of 134 enrolled, 122 completed. Topical arms increased U-zone sebum; only combined oral and topical treatment had a significant wrinkle-score advantage over dual placebo. Two participants stopping capsules were moved to the placebo-capsule analysis group.

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