Human oral care research
Treatment of aphthous stomatitis with saturated potassium nitrate/dimethyl isosorbide.
Quintessence international (Berlin, Germany : 1985) · 2004
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Dimethyl isosorbide was explicitly evaluated as the delivery component with potassium nitrate gel. No extractable sample size, randomization or independent dimethyl isosorbide efficacy is established from the abstract; oral mucosa differs from ordinary skin.
Checked against the published abstract on Oct 1, 2026. Read the source ↗
Abstract
Concentrated potassium nitrate has been used to lessen the pain caused by aphthous stomatitis. The problem with this approach is that it can have difficulty penetrating into the deeper layers of mucosae or skin, and for this reason, its beneficial affects are not routinely predictable. When dimethyl isosorbide is added to potassium nitrate in an aqueous hydroxyethyl cellulose gel, it enhances the capacity of potassium nitrate to more completely permeate these tissues and predictably promote rapid pain control and aphthae healing.
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